Pediatric post-transplant hepatic kaposi sarcoma due to donor-derived human herpesvirus 8.
Identifieur interne : 000262 ( Main/Exploration ); précédent : 000261; suivant : 000263Pediatric post-transplant hepatic kaposi sarcoma due to donor-derived human herpesvirus 8.
Auteurs : Karen E. Ocwieja [États-Unis] ; Sara O. Vargas [États-Unis] ; Scott A. Elisofon [États-Unis] ; David S. Shulman [États-Unis] ; Christine K. Lee [États-Unis] ; Rima Fawaz [États-Unis] ; Natalie Collins [États-Unis] ; Khashayar Vakili [États-Unis] ; Tanvi S. Sharma [États-Unis]Source :
- Pediatric transplantation [ 1399-3046 ] ; 2019.
Descripteurs français
- KwdFr :
- Atrésie des voies biliaires (chirurgie), Atrésie des voies biliaires (complications), Complications postopératoires (diagnostic), Donneurs de tissus (MeSH), Femelle (MeSH), Foie (imagerie diagnostique), Ganciclovir (usage thérapeutique), Herpèsvirus humain de type 8 (MeSH), Humains (MeSH), Imagerie par résonance magnétique (MeSH), Immunosuppression thérapeutique (MeSH), Mâle (MeSH), Nourrisson (MeSH), Paclitaxel (usage thérapeutique), Ponction-biopsie à l'aiguille (MeSH), Sarcome de Kaposi (virologie), Transplantation hépatique (effets indésirables), Évolution de la maladie (MeSH).
- MESH :
- chirurgie : Atrésie des voies biliaires.
- diagnostic : Complications postopératoires.
- effets indésirables : Atrésie des voies biliaires, Transplantation hépatique.
- imagerie diagnostique : Foie.
- usage thérapeutique : Ganciclovir, Paclitaxel.
- virologie : Sarcome de Kaposi.
- Donneurs de tissus, Femelle, Herpèsvirus humain de type 8, Humains, Imagerie par résonance magnétique, Immunosuppression thérapeutique, Mâle, Nourrisson, Ponction-biopsie à l'aiguille, Évolution de la maladie.
English descriptors
- KwdEn :
- Biliary Atresia (complications), Biliary Atresia (surgery), Biopsy, Needle (MeSH), Disease Progression (MeSH), Female (MeSH), Ganciclovir (therapeutic use), Herpesvirus 8, Human (MeSH), Humans (MeSH), Immunosuppression (MeSH), Infant (MeSH), Liver (diagnostic imaging), Liver Transplantation (adverse effects), Magnetic Resonance Imaging (MeSH), Male (MeSH), Paclitaxel (therapeutic use), Postoperative Complications (diagnosis), Sarcoma, Kaposi (virology), Tissue Donors (MeSH).
- MESH :
- chemical , therapeutic use : Ganciclovir, Paclitaxel.
- adverse effects : Liver Transplantation.
- complications : Biliary Atresia.
- diagnosis : Postoperative Complications.
- diagnostic imaging : Liver.
- surgery : Biliary Atresia.
- virology : Sarcoma, Kaposi.
- Biopsy, Needle, Disease Progression, Female, Herpesvirus 8, Human, Humans, Immunosuppression, Infant, Magnetic Resonance Imaging, Male, Tissue Donors.
Abstract
In areas of the world where human herpesvirus 8 (HHV-8) is endemic, Kaposi sarcoma (KS) is a common SOT-associated cancer. In the United States, where the virus is not prevalent, PTKS is rare, and there is little literature on pediatric PTKS. We present a North American female who underwent deceased donor, left lateral segment liver transplant for biliary atresia at age 11 months. The donor was a male with no known history of KS, originally from an HHV-8-endemic country. Three months after transplantation, the patient developed liver nodules and portal vein thrombosis. Analysis of needle biopsy established the diagnosis of KS and confirmed that the transformed cells were donor-derived. HHV-8 viremia was detected, and ganciclovir dosing (which had been started prophylactically) was increased. Immunosuppression was changed from tacrolimus to sirolimus. After further disease progression, 8 cycles of paclitaxel were administered. Under this treatment, her nodules regressed, HHV-8 viremia resolved, and she had marked clinic improvement. Notably, the adult recipient of the right liver lobe from the same donor also developed PTKS. This is one of few pediatric PTKS cases described in the literature. It contributes to the mechanistic understanding of PTKS development, illustrating the risk posed by donors from HHV-8-endemic countries, as well as the potential for strong PTKS correlation between multiple recipients of organs from a single shared donor.
DOI: 10.1111/petr.13384
PubMed: 30843320
Affiliations:
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Sharma</name><affiliation wicri:level="2"><nlm:affiliation>Division of Infectious Disease, Department of Pediatrics, Boston Children's Hospital, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Division of Infectious Disease, Department of Pediatrics, Boston Children's Hospital, Boston</wicri:cityArea></affiliation></author></analytic><series><title level="j">Pediatric transplantation</title><idno type="eISSN">1399-3046</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Biliary Atresia (complications)</term><term>Biliary Atresia (surgery)</term><term>Biopsy, Needle (MeSH)</term><term>Disease Progression (MeSH)</term><term>Female (MeSH)</term><term>Ganciclovir (therapeutic use)</term><term>Herpesvirus 8, Human (MeSH)</term><term>Humans (MeSH)</term><term>Immunosuppression (MeSH)</term><term>Infant (MeSH)</term><term>Liver (diagnostic imaging)</term><term>Liver Transplantation (adverse effects)</term><term>Magnetic Resonance Imaging (MeSH)</term><term>Male (MeSH)</term><term>Paclitaxel (therapeutic use)</term><term>Postoperative Complications (diagnosis)</term><term>Sarcoma, Kaposi (virology)</term><term>Tissue Donors (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Atrésie des voies biliaires (chirurgie)</term><term>Atrésie des voies biliaires (complications)</term><term>Complications postopératoires (diagnostic)</term><term>Donneurs de tissus (MeSH)</term><term>Femelle (MeSH)</term><term>Foie (imagerie diagnostique)</term><term>Ganciclovir (usage thérapeutique)</term><term>Herpèsvirus humain de type 8 (MeSH)</term><term>Humains (MeSH)</term><term>Imagerie par résonance magnétique (MeSH)</term><term>Immunosuppression thérapeutique (MeSH)</term><term>Mâle (MeSH)</term><term>Nourrisson (MeSH)</term><term>Paclitaxel (usage thérapeutique)</term><term>Ponction-biopsie à l'aiguille (MeSH)</term><term>Sarcome de Kaposi (virologie)</term><term>Transplantation hépatique (effets indésirables)</term><term>Évolution de la maladie (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Ganciclovir</term><term>Paclitaxel</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Liver Transplantation</term></keywords><keywords scheme="MESH" qualifier="chirurgie" xml:lang="fr"><term>Atrésie des voies biliaires</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Biliary Atresia</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Postoperative Complications</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Complications postopératoires</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Liver</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Atrésie des voies biliaires</term><term>Transplantation hépatique</term></keywords><keywords scheme="MESH" qualifier="imagerie diagnostique" xml:lang="fr"><term>Foie</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Biliary Atresia</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Ganciclovir</term><term>Paclitaxel</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Sarcome de Kaposi</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Sarcoma, Kaposi</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Biopsy, Needle</term><term>Disease Progression</term><term>Female</term><term>Herpesvirus 8, Human</term><term>Humans</term><term>Immunosuppression</term><term>Infant</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Tissue Donors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Donneurs de tissus</term><term>Femelle</term><term>Herpèsvirus humain de type 8</term><term>Humains</term><term>Imagerie par résonance magnétique</term><term>Immunosuppression thérapeutique</term><term>Mâle</term><term>Nourrisson</term><term>Ponction-biopsie à l'aiguille</term><term>Évolution de la maladie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In areas of the world where human herpesvirus 8 (HHV-8) is endemic, Kaposi sarcoma (KS) is a common SOT-associated cancer. In the United States, where the virus is not prevalent, PTKS is rare, and there is little literature on pediatric PTKS. We present a North American female who underwent deceased donor, left lateral segment liver transplant for biliary atresia at age 11 months. The donor was a male with no known history of KS, originally from an HHV-8-endemic country. Three months after transplantation, the patient developed liver nodules and portal vein thrombosis. Analysis of needle biopsy established the diagnosis of KS and confirmed that the transformed cells were donor-derived. HHV-8 viremia was detected, and ganciclovir dosing (which had been started prophylactically) was increased. Immunosuppression was changed from tacrolimus to sirolimus. After further disease progression, 8 cycles of paclitaxel were administered. Under this treatment, her nodules regressed, HHV-8 viremia resolved, and she had marked clinic improvement. Notably, the adult recipient of the right liver lobe from the same donor also developed PTKS. This is one of few pediatric PTKS cases described in the literature. It contributes to the mechanistic understanding of PTKS development, illustrating the risk posed by donors from HHV-8-endemic countries, as well as the potential for strong PTKS correlation between multiple recipients of organs from a single shared donor.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">30843320</PMID><DateCompleted><Year>2020</Year><Month>03</Month><Day>25</Day></DateCompleted><DateRevised><Year>2020</Year><Month>03</Month><Day>25</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1399-3046</ISSN><JournalIssue CitedMedium="Internet"><Volume>23</Volume><Issue>3</Issue><PubDate><Year>2019</Year><Month>05</Month></PubDate></JournalIssue><Title>Pediatric transplantation</Title><ISOAbbreviation>Pediatr Transplant</ISOAbbreviation></Journal><ArticleTitle>Pediatric post-transplant hepatic kaposi sarcoma due to donor-derived human herpesvirus 8.</ArticleTitle><Pagination><MedlinePgn>e13384</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/petr.13384</ELocationID><Abstract><AbstractText>In areas of the world where human herpesvirus 8 (HHV-8) is endemic, Kaposi sarcoma (KS) is a common SOT-associated cancer. In the United States, where the virus is not prevalent, PTKS is rare, and there is little literature on pediatric PTKS. We present a North American female who underwent deceased donor, left lateral segment liver transplant for biliary atresia at age 11 months. The donor was a male with no known history of KS, originally from an HHV-8-endemic country. Three months after transplantation, the patient developed liver nodules and portal vein thrombosis. Analysis of needle biopsy established the diagnosis of KS and confirmed that the transformed cells were donor-derived. HHV-8 viremia was detected, and ganciclovir dosing (which had been started prophylactically) was increased. Immunosuppression was changed from tacrolimus to sirolimus. After further disease progression, 8 cycles of paclitaxel were administered. Under this treatment, her nodules regressed, HHV-8 viremia resolved, and she had marked clinic improvement. Notably, the adult recipient of the right liver lobe from the same donor also developed PTKS. This is one of few pediatric PTKS cases described in the literature. It contributes to the mechanistic understanding of PTKS development, illustrating the risk posed by donors from HHV-8-endemic countries, as well as the potential for strong PTKS correlation between multiple recipients of organs from a single shared donor.</AbstractText><CopyrightInformation>© 2019 Wiley Periodicals, Inc.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ocwieja</LastName><ForeName>Karen E</ForeName><Initials>KE</Initials><Identifier Source="ORCID">0000-0002-1738-1634</Identifier><AffiliationInfo><Affiliation>Division of Infectious Disease, Department of Pediatrics, Boston Children's Hospital, Boston, Massachusetts.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vargas</LastName><ForeName>Sara O</ForeName><Initials>SO</Initials><AffiliationInfo><Affiliation>Department of Pathology, Boston Children's Hospital, Boston, Massachusetts.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Elisofon</LastName><ForeName>Scott A</ForeName><Initials>SA</Initials><AffiliationInfo><Affiliation>Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, Massachusetts.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shulman</LastName><ForeName>David S</ForeName><Initials>DS</Initials><AffiliationInfo><Affiliation>Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Christine K</ForeName><Initials>CK</Initials><AffiliationInfo><Affiliation>Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, Massachusetts.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fawaz</LastName><ForeName>Rima</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, Massachusetts.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Collins</LastName><ForeName>Natalie</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vakili</LastName><ForeName>Khashayar</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Surgery, Boston Children's Hospital, Boston, Massachusetts.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sharma</LastName><ForeName>Tanvi S</ForeName><Initials>TS</Initials><AffiliationInfo><Affiliation>Division of Infectious Disease, Department of Pediatrics, Boston Children's Hospital, Boston, Massachusetts.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D002363">Case Reports</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2019</Year><Month>03</Month><Day>06</Day></ArticleDate></Article><MedlineJournalInfo><Country>Denmark</Country><MedlineTA>Pediatr Transplant</MedlineTA><NlmUniqueID>9802574</NlmUniqueID><ISSNLinking>1397-3142</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>P88XT4IS4D</RegistryNumber><NameOfSubstance UI="D017239">Paclitaxel</NameOfSubstance></Chemical><Chemical><RegistryNumber>P9G3CKZ4P5</RegistryNumber><NameOfSubstance UI="D015774">Ganciclovir</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D001656" MajorTopicYN="N">Biliary Atresia</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000601" MajorTopicYN="Y">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001707" MajorTopicYN="N">Biopsy, Needle</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018450" MajorTopicYN="N">Disease Progression</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015774" MajorTopicYN="N">Ganciclovir</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019288" MajorTopicYN="Y">Herpesvirus 8, Human</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007165" MajorTopicYN="N">Immunosuppression</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007223" MajorTopicYN="N">Infant</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008099" MajorTopicYN="N">Liver</DescriptorName><QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016031" MajorTopicYN="N">Liver Transplantation</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008279" MajorTopicYN="N">Magnetic Resonance Imaging</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017239" MajorTopicYN="N">Paclitaxel</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011183" MajorTopicYN="N">Postoperative Complications</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012514" MajorTopicYN="N">Sarcoma, Kaposi</DescriptorName><QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014019" MajorTopicYN="N">Tissue Donors</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">human herpesvirus</Keyword><Keyword MajorTopicYN="Y">immunosuppression</Keyword><Keyword MajorTopicYN="Y">liver transplant</Keyword><Keyword MajorTopicYN="Y">malignancy</Keyword><Keyword MajorTopicYN="Y">pediatric transplantation</Keyword><Keyword MajorTopicYN="Y">virus</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2018</Year><Month>07</Month><Day>03</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2018</Year><Month>11</Month><Day>27</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2019</Year><Month>01</Month><Day>24</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2019</Year><Month>3</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>3</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2019</Year><Month>3</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">30843320</ArticleId><ArticleId IdType="doi">10.1111/petr.13384</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country><region><li>Massachusetts</li></region></list><tree><country name="États-Unis"><region name="Massachusetts"><name sortKey="Ocwieja, Karen E" sort="Ocwieja, Karen E" uniqKey="Ocwieja K" first="Karen E" last="Ocwieja">Karen E. Ocwieja</name></region><name sortKey="Collins, Natalie" sort="Collins, Natalie" uniqKey="Collins N" first="Natalie" last="Collins">Natalie Collins</name><name sortKey="Elisofon, Scott A" sort="Elisofon, Scott A" uniqKey="Elisofon S" first="Scott A" last="Elisofon">Scott A. Elisofon</name><name sortKey="Fawaz, Rima" sort="Fawaz, Rima" uniqKey="Fawaz R" first="Rima" last="Fawaz">Rima Fawaz</name><name sortKey="Lee, Christine K" sort="Lee, Christine K" uniqKey="Lee C" first="Christine K" last="Lee">Christine K. Lee</name><name sortKey="Sharma, Tanvi S" sort="Sharma, Tanvi S" uniqKey="Sharma T" first="Tanvi S" last="Sharma">Tanvi S. Sharma</name><name sortKey="Shulman, David S" sort="Shulman, David S" uniqKey="Shulman D" first="David S" last="Shulman">David S. Shulman</name><name sortKey="Vakili, Khashayar" sort="Vakili, Khashayar" uniqKey="Vakili K" first="Khashayar" last="Vakili">Khashayar Vakili</name><name sortKey="Vargas, Sara O" sort="Vargas, Sara O" uniqKey="Vargas S" first="Sara O" last="Vargas">Sara O. Vargas</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Bois/explor/RapamycinFungusV1/Data/Main/Exploration
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Ou
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Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Bois
|area= RapamycinFungusV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:30843320
|texte= Pediatric post-transplant hepatic kaposi sarcoma due to donor-derived human herpesvirus 8.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:30843320" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a RapamycinFungusV1
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